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G3 Forms New Collaborations for GLOBAL Study

Wednesday, February 26, 2014   (0 Comments)
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Global Genomics Group (G3) and Caprion Proteomics, Inc., today announced that they have entered into a collaboration agreement to investigate biological networks and pathways in order to discover novel biomarkers and pharmaceutical targets for cardiovascular diseases. Under the terms of the agreement, Caprion will identify blood-based protein markers for the GLOBAL (Genetic LOci and Burden of Atherosclerotic Lesions) study. GLOBAL is the largest pan-omic study combining genomics, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics and lipoprotein proteomics with coronary computed tomographic (CT) angiography, an advanced imaging technology for phenotyping, which allows  precise disease classification of patients.

"We will analyze 22 trillion data points from the precise CT phenotyping and the pan-omic analyses with specifically-developed systems and biology-based bioinformatics, allowing us to understand the root causes of cardiovascular disease and ultimately enable us to identify novel diagnostic biomarkers and therapeutic targets," said Szilard Voros, M.D., chief executive officer and co-founder of G3.  "Caprion's unbiased and targeted mass spectrometry-based proteomic platform will provide an in-depth assessment of plasma proteins to complement the other 'omic' approaches we are using in the GLOBAL study."

Caprion will utilize its CellCarta technology, an industrialized proteomic platform designed for large-scale studies, which is comprised of sample preparation, mass spectrometry, bioinformatics and biological expertise, to analyse and measure differential expression of proteins in plasma samples from the patients enrolled in GLOBAL. The ability to monitor and quantify large numbers of proteins in complex samples is key to understanding and treating complex diseases such as cardiovascular disease.

Earlier this month, Global Genomics Group and Quintiles announced a collaboration aimed at developing new diagnostic tools and treatments for cardiovascular diseases as part of the Genetic Loci and Burden of Atherosclerotic Lesions (GLOBAL) clinical study.

Under the agreement, Quintiles' Expression Analysis business will conduct RNA sequencing, miRNA sequencing, and methylation analysis in the study.

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