Apply for Peer Reviewed Orthopaedic Research Program Applied Research Award
Thursday, June 21, 2018
The FY18 PRORP challenges the scientific community to address the most significant gaps in care for the leading burden of injury and for facilitating return to duty by funding innovative, high-impact, clinically relevant research to advance optimal treatment and rehabilitation from neuromusculoskeletal injuries (excluding spinal cord injuries) sustained during combat or combat-related activities. It is expected that research findings would also benefit the general population. Applications involving multidisciplinary collaborations among academia, industry, the military Services, the Department of Veterans Affairs (VA), and other Federal agencies are highly encouraged.
An estimated 3,700 civilian amputations occur annually as a result of traumatic injury. In the military, extremity battle wounds comprise approximately 50% of injuries in the Joint Theater Trauma Registry. However, orthopaedic injuries and conditions that occur outside of combat (during training, leisure activities, resultant from old injuries, etc.) are the greatest threat to the readiness of our Service members and military. Early stabilization and treatment of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and loss of troop readiness. However, in potential future conflicts in rural areas, austere combat zones, or in mass casualty events, access to medical care may be delayed for hours, if not days or weeks.
Applications must address one of the following focus areas:
Animal Models: Develop animal models that replicate orthopaedic injuries or conditions that are challenging in a PFC scenario, such as ischemia reperfusion injury and compartment syndrome.
Device Development: Develop offloading and stability devices (e.g., braces, casting) for ligamentous injuries, small extremity fractures, and/or other non-severe common battlefield musculoskeletal injuries for immediate return to duty.
Wound Infection: Translate promising available clinical interventions in prevention and control of combat extremity wound infections (e.g., for long bone open fractures) to improve their durability to treat battlefield or trauma-related injuries as close as possible to the point of injury. Projects that further develop novel wound protectants for this population will also be considered.
Tissue Regeneration: Develop and conduct preclinical testing of therapies for volumetric muscle loss due to traumatically damaged tissues of the extremities.
There are three award mechanisms for PRORP:
1. Applied Research Award (you have the info for that already)
2. Clinical Trial Award (see below)
3. Clinical Translational Research Award (see below)
Clinical Trial Award (up to $3 million) – Areas of focus include:
· Surgical Techniques and Outcomes: Evaluate optimal surgical treatment strategies, tools, and delivery parameters in any of the below Surgical Care Areas to improve functional outcomes for immediate return to duty/work for Service members and other individuals who have sustained orthopaedic injuries.
o Surgical Care Areas: Peripheral Nerve Injuries, Prevention of Heterotopic Ossification, Volumetric Muscle Loss, Extremity Fractures, Pelvic Ring Injuries, Compartment Syndrome, Gaps in Clinical Practice Guidelines, Surgical Techniques to Optimize Gait, Soft Tissue Trauma, and Osteoarthritis.
· Rehabilitation Techniques and Outcomes: Evaluate optimal rehabilitation treatment strategies, tools, and delivery parameters to improve functional outcomes for early return to duty/work for Service members and other individuals who have sustained orthopaedic injuries.
· Acute Pain: Evaluate promising available or emerging clinical interventions to control acute pain (e.g., analgesics, anti-inflammatory agents, nerve blocks) following orthopaedic injuries in the pre-hospital setting. Projects that investigate a pathway to enhance non-physician capabilities to deliver rapid, long-lasting analgesia with minimal cognitive side effects in an austere environment are encouraged.
· Improved Surgical Interventions: Develop or optimize orthopaedic surgical devices/ interventions to support their use in the pre-hospital environment.
· Tissue Regeneration: Evaluate advanced regenerative medicine therapeutics for restoration of traumatically injured extremity tissues.
Pre-proposal Due: 7/30/18 (will be notified 9/5/18 if invited to submit full proposal)
Full Proposal: By Invitation only, and will be due 10/24/18
Clinical Translational Research Award (up to $2 million) – Areas of focus include:
· Treatment Techniques and Outcomes: Develop and/or evaluate optimal non-surgical and/or surgical treatment strategies and intervention delivery parameters (e.g., frequency, intensity, time, and intervention type) to rapidly remediate duty-limiting impairments, functional limitations, or barriers to full duty readiness following orthopaedic injuries. Interventions may include but are not limited to: combination therapies (simultaneous application of multiple treatment modalities), injections, dry needling, manual therapy, therapeutic exercise, or other techniques to return Service members and other individuals to duty/work within 72 hours.
· Wound Infection: Evaluate and/or translate promising available clinical interventions in prevention and control of combat extremity wound infections (e.g., for long bone open fractures) to improve their durability to treat battlefield or trauma-related injuries as close as possible to the point of injury. Projects that further develop novel wound protectants for this population will also be considered.
· Surgical Care: Translate early research findings, in any of the below surgical care areas, to humans.
o Surgical Care Areas: Peripheral Nerve Injuries, Prevention of Heterotopic Ossification, Volumetric Muscle Loss, Extremity Fractures, Pelvic Ring Injuries, Compartment Syndrome, Gaps in Clinical Practice Guidelines, Surgical Techniques to Optimize Gait, Soft Tissue Trauma, Osteoarthritis. See Appendix 2 for a more detailed description of each surgical care area.
· Tissue Regeneration: Develop and/or evaluate regenerative medicine therapies (devices, drugs, biologics, and/or techniques) for traumatically injured tissues of the extremities.
Full proposals by invitation only
Pre-proposals invited to submit will be notified 9/5/18 with full proposals due 10/24/18