Blood Test May Revolutionize Brain Cancer Diagnosis
Monday, August 25, 2014
Scientists at Virginia Tech's Virginia Bioinformatics Institute working with the Center for Cancer and Blood Disorders at Children’s National Medical Center have found a new way to diagnose brain cancer based on genetic markers found in "junk DNA."
The finding, recently published in Oncotarget, could revolutionize the way doctors treat certain brain cancers, the second leading cancer-related cause of death in children.
According to the American Brain Tumor Association, 70,000 new patients were diagnosed with primary brain tumors in 2013, but only about a third turn out to be malignant. Ordinarily, when a patient shows symptoms of a brain tumor, an MRI is performed to locate tumors, but it cannot determine whether the tumor is benign or malignant, often necessitating costly and occasionally dangerous or inconclusive biopsies.
A simple blood test to detect genetic markers could change all that.
"Patients with less aggressive types of cancer as determined by this test would not need a biopsy," said Harold 'Skip' Garner, a professor and director of the Medical Informatics and Systems Division at the Virginia Bioinformatics Institute. "The biopsy is expensive both medically and financially — one percent of patients die and seven percent have permanent neurological damage from the procedure, according to the Canadian Journal of Neurology. This finding may reduce costs and save lives."
The study analyzed germline (blood) sequences from the National Institutes of Health 1000 Genomes Project and the Cancer Genome Atlas. Analyzing the microsatellites, long dismissed as "junk DNA”, from these sequences revealed that patients with various stages of glioma showed recognizable and consistent markers in their genomes for the disease.
This information indicates it is possible to develop a simple blood test that would help identify patients with different brain cancer grades, likely reducing invasive and inconclusive brain biopsies. These new, microsatellite-based diagnostics are applicable to many other cancers and diseases. It is hoped that with continued study, more markers and potential drug targets or therapies will be found.